Absence of structural alterations of the multidrug resistance genes in transitional cell carcinoma Academic Article Article uri icon


MeSH Major

  • Disease Models, Animal
  • Fragile X Syndrome
  • Mutation, Missense


  • Tumor DNA from 27 patients with treated or untreated transitional cell carcinomas of the urinary tract was screened for genomic alterations of the multidrug resistance genes in order to determine whether structural changes of these genes are important in primary urothelial tumors. None of the tumors showed evidence of amplification or rearrangements of either mdr1 or mdr2. The lack of amplification or rearrangements observed in these tumors suggests that structural alterations of the mdr1 and mdr2 genes are not important mediators of drug resistance in TCC.

publication date

  • July 1990



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/BF00294774

PubMed ID

  • 2219592

Additional Document Info

start page

  • 281

end page

  • 6


  • 18


  • 4