Indium-111-labeled leukocyte and technetium-99m-sulfur colloid uptake by a malignant fibrous histiocytoma: Phagocytosis by tumor cells? Academic Article uri icon


MeSH Major

  • Histiocytoma, Benign Fibrous
  • Indium Radioisotopes
  • Leukocytes
  • Phagocytosis
  • Soft Tissue Neoplasms
  • Technetium Tc 99m Sulfur Colloid


  • Indium-111-labeled leukocyte imaging, performed on a patient with a calcified mass in the right thigh, demonstrated labeled leukocyte accumulation in this mass. Technetium-99m-sulfur colloid imaging was performed to differentiate labeled leukocyte uptake in heterotopic bone marrow from uptake in a focus of infection. Leukocyte and sulfur colloid images were virtually identical, and the study was interpreted as without evidence of infection. Excision of the mass revealed an angiomatoid malignant fibrous histiocytoma with metaplastic bone formation. While no marrow elements were present in either the tumor or the metaplastic bone, phagocytosis of leukocytes by tumor cells was identified. Phagocytosis of leukocytes by tumor cells may be another cause of white cell accumulation in uninfected neoplasms.

publication date

  • January 1990



  • Academic Article



  • eng

PubMed ID

  • 2168475

Additional Document Info

start page

  • 1548

end page

  • 51


  • 31


  • 9