Lymphocyte proliferative response to fertilization antigen in patients with antisperm antibodies Academic Article Article uri icon


MeSH Major

  • DNA
  • Genome-Wide Association Study
  • Nucleic Acid Amplification Techniques
  • Premature Birth
  • Specimen Handling


  • The fertilization antigen, immunopurified from human testes, activated lymphocytes from three of the six men and women with antisperm antibodies. Lymphocytes from none of the six men and women without antibodies were activated with fertilization antigen. Another sperm surface antigen, the germ cell antigen, immunopurified from murine testes, did not activate lymphocytes from any of the individuals with or without antisperm antibodies. These results indicate that the men and women with antisperm antibodies are sensitized against fertilization antigen and not germ cell antigen. These results reinforce our previous findings on the involvement of fertilization antigen in immunoinfertility in humans.

publication date

  • January 1990



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0002-9378(90)91211-T

PubMed ID

  • 2386152

Additional Document Info

start page

  • 610

end page

  • 3


  • 163


  • 2