A highly immunogenic tumor transfected with a murine transforming growth factor type β1 cDNA escapes immune surveillance Academic Article uri icon

Overview

MeSH Major

  • Fibrosarcoma
  • Immunity, Cellular
  • Immunologic Surveillance
  • Sarcoma, Experimental
  • Transfection
  • Transforming Growth Factors

abstract

  • A highly immunogenic C3H-derived UV-induced tumor was cotransfected with a murine transforming growth factor type beta 1 (TGF-beta 1) cDNA and a neomycin-resistance gene. Stable clones were isolated and used in vitro and in vivo to determine the effects of endogenously produced TGF-beta on cytolytic T-lymphocyte (CTL) responses. Tumor cells producing TGF-beta, though retaining expression for class I major histocompatibility complex molecules and the tumor-specific antigen, did not stimulate primary CTL responses in vitro and were not effective in vivo for directly stimulating primary CTL or in priming for CTL responses. Furthermore, TGF-beta-producing tumors grew progressively in transiently immunosuppressed mice without losing the tumor antigen; thus, TGF-beta produced by tumors may promote escape from immune surveillance.

publication date

  • March 12, 1990

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC53500

PubMed ID

  • 2137615

Additional Document Info

start page

  • 1486

end page

  • 90

volume

  • 87

number

  • 4