IgM deposits at nodes of Ranvier in a patient with amyotrophic lateral sclerosis, anti-GM1 antibodies, and multifocal motor conduction block Academic Article uri icon


MeSH Major

  • Amyotrophic Lateral Sclerosis
  • Antibodies
  • G(M1) Ganglioside
  • Immunoglobulin M
  • Neuromuscular Diseases
  • Ranvier's Nodes


  • We studied a patient with amyotrophic lateral sclerosis, multifocal motor conduction block, and IgM anti-GM1 antibodies. A sural nerve biopsy demonstrated deposits of IgM at nodes of Ranvier by direct immunofluorescence. The deposits were granular and located in the nodal gap between adjacent myelin internodes, and in some instances, they extended along the surface of the paranodal myelin sheath. When injected into rat sciatic nerve, the serum IgM bound to the nodes of Ranvier, and the binding activity was removed by preincubation with GM1. These observations suggest that anti-GM1 antibodies may have caused motor dysfunction by binding to the nodal and paranodal regions of peripheral nerve.

publication date

  • October 2, 1990



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1002/ana.410280312

PubMed ID

  • 2132741

Additional Document Info

start page

  • 373

end page

  • 7


  • 28


  • 3