Mechanisms of abnormal transmembrane signaling of the β-adrenergic receptor in congestive heart failure Review uri icon

Overview

MeSH Major

  • Heart Failure
  • Receptors, Adrenergic, beta
  • Signal Transduction

abstract

  • Congestive heart failure is associated with blunted cardiac adrenergic responsiveness, clinically manifested by diminished chronotropic, inotropic, and lusitropic responses to beta-adrenergic stimulation. Recent advances in our understanding of the multiple components of the beta-adrenergic receptor complex and of the mechanisms by which these components interact with each other have led to insights beyond the mere evaluation of beta-receptors to account for adrenergic hyporesponsiveness in congestive heart failure. In addition to a reduction in beta-adrenergic receptors, the failing heart appears to show key abnormalities in the guanine nucleotide-binding proteins that link the beta-receptor to its biochemical effector. A reduction in the stimulatory protein and in the extent to which the stimulatory protein is linked to the beta-receptor are demonstrable in peripheral circulating lymphocytes and in cardiac tissue. These abnormalities are at least partially reversible.

publication date

  • January 1990

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 2164895

Additional Document Info

start page

  • I26

end page

  • 34

volume

  • 82

number

  • 2 SUPPL.