Electrophysiologic study of experimental demyelination induced by serum of patients with IgM M proteins and neuropathy Academic Article uri icon


MeSH Major

  • Blood Proteins
  • Demyelinating Diseases
  • Immunoglobulin M
  • Immunoglobulins
  • Myelin Sheath


  • We induced progressive conduction block in feline sciatic nerve by endoneurial injection of serum from 2 patients with demyelinating neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M protein. The block was longlasting (up to 4 days) and affected about half the motor nerve fibers. Control serum from patients with an IgM M protein that did not react with MAG produced a transient block (less than 48 hours) that affected an average of 25% of motor fibers. Nerves with sustained block showed widespread demyelination of many nerve fibers, exceeding controls. The findings support the view that chronic demyelinating neuropathy in these patients is caused by the anti-MAG M protein.

publication date

  • December 1989



  • Academic Article



  • eng

PubMed ID

  • 2479887

Additional Document Info

start page

  • 1581

end page

  • 6


  • 39


  • 12