Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. Academic Article Article uri icon


MeSH Major

  • Action Potentials
  • Arrhythmias, Cardiac
  • Calcium
  • Calcium Signaling
  • Calmodulin
  • Voltage-Gated Sodium Channels


  • Previous results have shown that chemotaxis and the expression of several classes of genes in Dictyostelium discoideum are regulated through a cell surface cAMP receptor interacting with guanine nucleotide-binding proteins (G proteins). We now describe cloning and sequencing of cDNAs encoding two G alpha protein subunits from Dictyostelium. The derived amino acid sequences show that they are 45% identical to each other and to G alpha protein subunits from mammals and yeast. Both cDNAs are complementary to multiple mRNAs that are differentially expressed during development. This evidence and analysis of mutants presented elsewhere suggest that they have distinct physiological functions.

publication date

  • July 1989



  • Academic Article


PubMed ID

  • 2500658

Additional Document Info

start page

  • 4892

end page

  • 6


  • 86


  • 13