Detection of abnormalities in febrile AIDS patients with In-111-labeled leukocytes and Ga-67 scintigraphy Academic Article uri icon

Overview

MeSH Major

  • Acquired Immunodeficiency Syndrome
  • Bacterial Infections
  • Colitis
  • Fever of Unknown Origin
  • Gallium Radioisotopes
  • Indium Radioisotopes
  • Pneumonia, Pneumocystis

abstract

  • Thirty-six patients with acquired immunodeficiency syndrome (AIDS), who were febrile but without localizing signs, underwent indium-111 leukocyte scintigraphy 24 hours after injection of labeled white blood cells (WBCs) and were restudied 48 hours after injection of gallium-67 citrate. Fifty-six abnormalities were identified as possible sources of the fever; 27 were confirmed with biopsy. Of these 27, 15 were identified only on In-111 WBC scans (including colitis, sinusitis, and focal bacterial pneumonia); six, only on Ga-67 scans (predominantly Pneumocystis carinii pneumonia and lymphadenopathy); and six, on both studies (predominantly pulmonary lesions). In-111 WBC scanning revealed 21 of 27 abnormalities (78%) and gallium scanning, 12 of 27 (44%). If only one scintigraphic study has been performed, particularly with Ga-67, a significant number of lesions would not have been detected. The authors believe radionuclide evaluation of the febrile AIDS patient without localizing signs should begin with In-111 WBC scintigraphy. Gallium scanning may be used depending on results of In-111 WBC scans or if there is a high index of suspicion for P carinii pneumonia.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2783783

Additional Document Info

start page

  • 677

end page

  • 80

volume

  • 170

number

  • 3 I