Prognostic factors for relapse after complete response in patients with metastatic germ cell tumors Academic Article Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Early Detection of Cancer
  • Mammary Glands, Human
  • Mammography
  • Ultrasonography, Mammary

abstract

  • Among 216 patients with metastatic germ cell tumors who achieved a complete response (CR) to cisplatin-based chemotherapy (CT), 38 have experienced a relapse. Prognostic factors for time to relapse from time of response were considered using the Cox proportional hazards model. Compared with patients who responded to CT and did not require surgery and patients whose surgery showed only either necrotic debris or mature teratoma, those who required surgery for residual tumor after CT were at much higher risk for relapse, although their residual tumor was totally resected. Of the 19 patients who required this surgery, eight have experienced a relapse. Other prognostic factors for relapse included lactate dehydrogenase (LDH) and human chorionic gonadatropin (hCG) at the time of initial CT. Although those who require surgery for residual tumor after CT receive additional CT, there is still a high risk of relapse.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19890201)63:3<440::AID-CNCR2820630308>3.0.CO;2-7

PubMed ID

  • 2912523

Additional Document Info

start page

  • 440

end page

  • 5

volume

  • 63

number

  • 3