Ectopic production of the β-subunit of human chorionic gonadotropin in osteosarcoma Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Bone Neoplasms
  • Chorionic Gonadotropin
  • Osteosarcoma
  • Peptide Fragments

abstract

  • Production of human chorionic gonadotropin by sarcomas is an uncommon phenomenon that has rarely been documented. A case of a 26-year-old woman with osteosarcoma of the left fibula and high levels of serum beta-human chorionic gonadotropin (beta-HCG) is described. Immunoperoxidase staining showed numerous tumor cells reacting with the beta-HCG antibody. Immunohistochemical studies performed on ten additional osteosarcomas demonstrated another case in which some tumor cells presented immunoreactivity for beta-HCG. These results indicate that beta-HCG may be used as a marker of persistent or recurrent disease in those uncommon cases of osteosarcoma in which serum levels of beta-HCG are elevated at the onset of treatment.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2468324

Additional Document Info

start page

  • 416

end page

  • 9

volume

  • 113

number

  • 4