The St. Jude Valve prosthesis: Analysis of the clinical results in 815 implants and the need for systemic anticoagulation Academic Article Article uri icon


MeSH Major

  • Heart Valve Prosthesis Implantation
  • Image Enhancement
  • Magnetic Resonance Imaging, Cine
  • Mitral Valve
  • Mitral Valve Insufficiency


  • Between July 1979 and December 1984, 785 patients received 815 St. Jude Medical valve prostheses. Valve-related mortality in the follow-up period was due to thromboembolism in seven cases, anticoagulant-related hemorrhage in three and perivalvular leak in two. Freedom from valve-related death or reoperation at 3 years was 96.4% for aortic valve replacement and 98.3% for mitral valve replacement. The overall rate of thromboembolism was 2.6%/patient-year with warfarin, 9.2%/patient-year with antiplatelet medication and 15.6%/patient-year in patients with no anticoagulant therapy. One episode of thrombotic obstruction of a mitral valve, in a patient receiving no anticoagulant therapy, resulted in an occurrence rate of such obstruction of 0.22%/patient-year. Valve replacement with the St. Jude valve produced excellent clinical results, but long-term anticoagulation with warfarin was required to minimize thromboembolic complications. The use of antiplatelet agents alone provided inadequate protection.

publication date

  • January 1989



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0735-1097(89)90549-4

PubMed ID

  • 2909582

Additional Document Info

start page

  • 57

end page

  • 62


  • 13


  • 1