Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice Academic Article Article uri icon

Overview

MeSH Major

  • Gastric Mucosa
  • Gastrointestinal Diseases
  • Intestinal Mucosa
  • Oxidative Stress
  • Reactive Oxygen Species

abstract

  • 3-Methyladenine-DNA N-glycosylase (MAG) and O6-methylguanine-DNA methyltransferase (MGMT) activities were assayed in liver, lungs, brain and ovaries of female mice of two inbred stocks, C3Hf and C57BL/E, as a function of age. In addition to differences in the enzyme levels between the two stocks for each organ, the suckling animals (9-day-old) have consistently lower levels of both MAG and MGMT than young adults (7- or 8-week-old). While the MGMT levels in adults did not decrease with age, the MAG levels in 15- to 17-month-old animals were, in general, significantly lower than those in young adults. These results raise the possibility that the older animals are at a higher risk than young adults following exposure to alkylating mutagens.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0047-6374(89)90024-9

PubMed ID

  • 2725074

Additional Document Info

start page

  • 43

end page

  • 52

volume

  • 48

number

  • 1