Circulating interferon-γ in women sensitized to sperm: New mechanisms of infertility Academic Article uri icon

Overview

MeSH Major

  • Immunization
  • Infertility
  • Interferon-gamma
  • Spermatozoa

abstract

  • The relationship between antisperm antibodies and IFN-gamma production was examined. Interferon-gamma was identified in 15 of 40 sera (37.5%) from women with antisperm antibodies, but in only 2 of 28 sera (7.4%) from women who lacked these antibodies. In four of six women with circulating antisperm antibodies, but in zero of six controls, in vitro incubation of their peripheral blood mononuclear cells led to the spontaneous release of both antisperm antibodies and IFN-gamma. In women sensitized to sperm, coitus-induced IFN-gamma production may impair fertility and early embryo development by mechanisms other than a direct effect of antisperm antibodies on the male gamete.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2509256

Additional Document Info

start page

  • 867

end page

  • 9

volume

  • 52

number

  • 5