The distribution of glycosyl-phosphatidylinositol anchored proteins is differentially regulated by serum and insulin Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Leukemia, Myeloid, Acute

abstract

  • Glycosyl-phosphatidylinositol (GPI) anchored proteins are surveyed in two insulin sensitive cell types by surface labeling and phospholipase C-induced release into the medium. Serum starvation selectively increases both the number and intensity of a subset of GPI-anchored proteins. After serum starvation, loss of cell-surface GPI-anchored proteins is induced acutely by either serum re-exposure or insulin, suggesting that hormonal treatment may promote the release of these proteins from the cell surface.

publication date

  • October 31, 1989

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0006-291X(89)91533-7

PubMed ID

  • 2530980

Additional Document Info

start page

  • 824

end page

  • 32

volume

  • 164

number

  • 2