Role of nuclear grading in stage I renal cell carcinoma Academic Article Article uri icon


MeSH Major

  • Blood Pressure Determination
  • Hypertension
  • Self Care


  • Through a retrospective histologic analysis of 55 cases of Stage I renal cell carcinoma, we evaluated the usefulness of the nuclear grading system (Fuhrman, Lasky, Limas) in identifying those tumors that will eventually metastasize and kill the patient. The difference in five-year survival rates between patients with combined nuclear grade 1-3 tumors (n = 50, 91%) and grade 4 tumors (n = 5, 9%) was significant (P less than 0.0046). Other predictors of death due to renal cell carcinoma included: tumor size greater than 8 cm (P less than 0.001) and mitoses greater than one per 10 high-power field (P less than 0.01). Within Stage I tumors, therefore, nuclear grade is an important morphologic variable for predicting long-term survival. Identification of nuclear grade 4 neoplasms may become prognostically indispensable to determine the metastatic potential of early-stage tumors and thereby to institute appropriate systemic therapy.

publication date

  • January 1989



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0090-4295(89)90333-6

PubMed ID

  • 2815458

Additional Document Info

start page

  • 310

end page

  • 5


  • 34


  • 5