Correlation of sperm-bound immunoglobulins with impaired semen analysis in infertile men with varicoceles Academic Article uri icon


MeSH Major

  • Immunoglobulins
  • Infertility, Male
  • Semen
  • Spermatozoa
  • Varicocele


  • Sperm-bound immunoglobulins were found in 27 (32%) of 84 infertile men with palpable varicoceles. These men were divided into two groups based on the presence (group I; 32%) or absence (group II; 68%) of sperm-bound immunoglobulins, as measured by an enzyme-linked immunosorbent assay. Circulating antisperm antibodies were identified in 52% of patients with sperm-bound immunoglobulins and 14% of group II patients. The presence of sperm-bound immunoglobulins was associated with a small but significant decrease in both sperm concentration and motility. Sperm-bound immunoglobulins are present in a greater percentage of infertile men with varicoceles than infertile men without varicoceles. Their presence may be a marker for damage to the seminiferous epithelia in men with varicoceles and may also contribute to varicocele-associated infertility.

publication date

  • January 1989



  • Academic Article



  • eng

PubMed ID

  • 2506079

Additional Document Info

start page

  • 469

end page

  • 73


  • 52


  • 3