Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients Academic Article uri icon

Overview

MeSH Major

  • DNA-Directed DNA Polymerase
  • Hepatitis B
  • Hepatitis B Antibodies

abstract

  • By the use of a truncated recombinant hepatitis B virus polymerase antigen, we have characterized a series of patient sera for anti-hepatitis B virus polymerase antibodies. Seven of 54 (13%) had antipolymerase antibodies detectable by Western blot analysis, and no close correlation was apparent between the disease status and patient's immune response against hepatitis B virus polymerase antigen. Our results indicate that serologic responses to the viral polymerase are demonstrable but suggest that such antibodies are not likely to be clinically useful as diagnostic or prognostic markers of infection.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2759550

Additional Document Info

start page

  • 332

end page

  • 5

volume

  • 10

number

  • 3