S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets Academic Article uri icon

Overview

MeSH Major

  • Angiotensin-Converting Enzyme Inhibitors
  • Captopril
  • Platelet Aggregation Inhibitors
  • Vasodilator Agents

abstract

  • We have synthesized an S-nitrosylated derivative of captopril, S-nitrosocaptopril, that manifests nitrosovasodilatory activity, inhibits angiotensin converting enzyme activity and inhibits platelet aggregation. The direct vasodilatory effects of S-nitrosocaptopril reflect the effects of the thionitrite bond, the presence of which does not in any way influence S-nitrosocaptopril's ability to inhibit angiotensin converting enzyme. Thionitrite stimulation of both vascular and platelet soluble guanylate cyclase activity leads to increases in intracellular cyclic GMP that are accompanied by vasodilatation and platelet inhibition, respectively. S-nitrosocaptopril is a novel hybrid molecule that has potential use in the treatment of hypertension regardless of renin status, angina pectoris and congestive heart failure.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2659776

Additional Document Info

start page

  • 726

end page

  • 9

volume

  • 249

number

  • 3