Failure of sperm-induced immunosuppression: Association with antisperm antibodies in women Academic Article Article uri icon


MeSH Major

  • DNA
  • Genome-Wide Association Study
  • Nucleic Acid Amplification Techniques
  • Premature Birth
  • Specimen Handling


  • The ability of husbands' sperm to inhibit proliferation of their wives' lymphocytes was measured. Seventeen of 27 sperm samples tested (63%) inhibited lymphocytes from responding to Candida antigens. Eleven of the 27 women (41%) had sera that were positive for antisperm antibodies; sperm from only four of their husbands (36%) were immunosuppressive. In contrast, 13 of the 16 women (81%) without antisperm antibodies had partners with suppressive sperm. Lymphocytes from four women with antisperm antibodies were inhibited by sperm from a fertile donor although not inhibited by their husband's sperm, whereas in three other antibody-positive women neither the husbands' nor donors' sperm were inhibitory. Antisperm antibodies in some women may arise as a consequence of a failure of sperm from their male partners to inhibit lymphocyte activation.

publication date

  • January 1989



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0002-9378(89)90181-6

PubMed ID

  • 2658605

Additional Document Info

start page

  • 1166

end page

  • 8


  • 160


  • 5 PART 1