Failure of cytotoxic chemotherapy, 1983-1988, and the emerging role of monoclonal antibodies for renal cancer Review uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Carcinoma, Renal Cell
  • Kidney Neoplasms

abstract

  • A review of 36 cytotoxic agents used singly in over 1,900 patients with renal cancer between 1983 and 1988 finds marginal antitumor activity, less than 5-10%. The future role of monoclonal antibodies for therapy of this disease may offer some hope with the recent description of rather specific phenotypic expression, URO 10+/URO 8+, suggesting the cell origin of most renal tumors from the distal portion of the proximal tubule.

publication date

  • January 1989

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 2696193

Additional Document Info

start page

  • 338

end page

  • 45

volume

  • 44

number

  • 6