High levels of transforming growth factor-beta are present in the epithelial lining fluid of the normal human lower respiratory tract. Academic Article uri icon

Overview

MeSH

  • Adult
  • Cell Division
  • Chromatography, Gel
  • Epithelium
  • Female
  • Fibroblasts
  • Humans
  • Male
  • Reference Values

MeSH Major

  • Bronchoalveolar Lavage Fluid
  • Lung
  • Transforming Growth Factors

abstract

  • Transforming growth factor-beta (TGF-beta), a mediator capable of modulating a broad range of effects on the behavior of many normal cells, was found in high concentrations in the epithelial lining fluid (ELF) of the normal human lower respiratory tract. Although plasma contained small amounts of TGF-beta, the concentrations of TGF-beta in normal ELF were in the 200 to 300 pM range, more than 15-fold higher. This ELF TGF-beta had similar physical characteristics to purified human platelet TGF-beta, competed with platelet TGF-beta for its receptor on A549 carcinoma cells, and stimulated the anchorage-independent growth of NRK cells in soft agar in the presence of epidermal growth factor. Furthermore, ELF TGF-beta suppressed diploid lung fibroblast proliferation in a dose-dependent fashion similar to platelet TGF-beta. In the context of these observations and with the known biologic properties of this molecule, TGF-beta in ELF has the potential to play a role in a variety of cellular processes in the lower respiratory tract.

publication date

  • June 1988

has subject area

  • Adult
  • Bronchoalveolar Lavage Fluid
  • Cell Division
  • Chromatography, Gel
  • Epithelium
  • Female
  • Fibroblasts
  • Humans
  • Lung
  • Male
  • Reference Values
  • Transforming Growth Factors

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1164/ajrccm/137.6.1360

PubMed ID

  • 3202372

Additional Document Info

start page

  • 1360

end page

  • 1363

volume

  • 137

number

  • 6