Immunohistochemical characterization of pulmonary blastoma Academic Article uri icon

Overview

MeSH Major

  • Carcinosarcoma
  • Immunohistochemistry
  • Lung Neoplasms

abstract

  • The immunohistochemical staining patterns of three pulmonary blastomas (PBs) were studied for markers of mesenchymal (vimentin, muscle-specific actin) and epithelial (cytokeratin, epithelial membrane antigen) differentiation to clarify their phenotypic nature and, possibly, their histogenesis. Epithelial markers were confined to the tubular component of the tumors, and the mesenchymal markers were confined to the stromal component, demonstrating that PBs are true mixed tumors. These findings are consistent with origin from a primitive pluripotential stem cell but do not rule out derivation from a single germ layer with subsequent metaplastic transformation.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3369370

Additional Document Info

start page

  • 773

end page

  • 7

volume

  • 89

number

  • 6