A clinicopathologically distinctive primary splenic histiocytic neoplasm. Demonstration of its histiocytic derivation by immunophenotypic and molecular genetic analysis Academic Article uri icon

Overview

MeSH Major

  • Histiocytes
  • Splenic Neoplasms

abstract

  • We describe a primary splenic neoplasm composed of cytomorphologically malignant-appearing erythrophagocytic histiocytoid cells reminiscent of those seen in malignant histiocytosis. However, this neoplasm displayed certain distinctive clinicopathologic features--including localization to the spleen, where it grew as separate discrete nodules--that distinguish it from all previously reported cases of malignant histiocytosis. The cells expressed a monocyte/histiocyte immunophenotype and lacked clonal immunoglobulin and T-cell receptor beta-chain gene rearrangements. Our results suggest that this neoplasm represents a clinicopathologically distinctive and possibly unique tumor derived from the tissue macrophage lineage.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3284398

Additional Document Info

start page

  • 398

end page

  • 404

volume

  • 12

number

  • 5