Monoclonal IgM with unique specificity to gangliosides GM1 and GD(1b) and to lacto-N-tetraose associated with humen motor neuron disease Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Gangliosides
  • Immunoglobulin M
  • Motor Neurons
  • Neuromuscular Diseases
  • Oligosaccharides

abstract

  • IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM1 and GD1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2452383

Additional Document Info

start page

  • 763

end page

  • 8

volume

  • 38

number

  • 5