Colonic Neoplasms in Asymptomatic First‐Degree Relatives of Colon Cancer Patients Academic Article Article uri icon


MeSH Major

  • Catheterization, Central Venous
  • Ultrasonography, Interventional
  • Veins


  • First-degree relatives of colon cancer patients are at elevated risk for developing colorectal neoplasms. In order to assess the potential usefulness of screening by colonoscopy in this high-risk population, we reviewed the records of 48 colonoscopies performed on asymptomatic patients who were self- or physician-referred for colonoscopy because of a history of one or more first-degree relatives with colon cancer. Twelve (25%) had at least one adenomatous polyp, but no significant atypia was detected. No cancers were detected. One third of the lesions were beyond the reach of a flexible sigmoidoscope. This apparent increase in the prevalence of adenomas was most striking (46%) among men over the age of 50. These preliminary results demonstrate that colonoscopy is effective in detecting and removing adenomatous polyps in a substantial fraction of asymptomatic patients whose sole risk-factor is being a first-degree relative of a patient with colon cancer. Further studies in larger populations are warranted to determine the use of colonoscopy in screening these high-risk individuals.

publication date

  • January 1988



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1111/j.1572-0241.1988.tb02342.x

PubMed ID

  • 3344729

Additional Document Info

start page

  • 271

end page

  • 3


  • 83


  • 3