Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor Academic Article uri icon

Overview

MeSH Major

  • Growth Substances
  • Motor Neurons

abstract

  • Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5 to 10) rescues a significant number of motoneurons from degeneration. The survival activity of partially purified extract was dose-dependent and developmentally regulated. The survival of sensory, sympathetic, parasympathetic, and a population of cholinergic sympathetic preganglionic neurons was unaffected by treatment with hindlimb extract. The massive motoneuron death that occurs after early target (hindlimb) removal was partially ameliorated by daily treatment with the hindlimb extract. These results indicate that a target-derived neurotrophic factor is involved in the regulation of motoneuron survival in vivo.

publication date

  • December 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3363373

Additional Document Info

start page

  • 919

end page

  • 22

volume

  • 240

number

  • 4854