Sarcoidosis is not associated with a generalized defect in T cell suppressor function. Academic Article uri icon

Overview

MeSH

  • Adult
  • Cells, Cultured
  • Female
  • Humans
  • Immune Tolerance
  • Lymphocyte Activation
  • Male
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • T-Lymphocytes, Helper-Inducer

MeSH Major

  • Lung Diseases
  • Sarcoidosis
  • T-Lymphocytes, Regulatory

abstract

  • In pulmonary sarcoidosis, the marked expansion of CD4+ (helper/inducer) T cells in the alveolar structures of the lung is maintained by local IL-2 release by activated CD4+ HLA-DR+ T cells without concomitant expansion and activation of CD8+ (suppressor/cytotoxic) T cells, suggesting that sarcoid may be associated with a generalized abnormality of CD8+ T cells. Consistent with this concept, evaluation of the expression of the IL-2R on fresh lung T cells from individuals with active sarcoidosis demonstrated that 7 +/- 1% of sarcoid lung CD4+ T cells are spontaneously expressing the IL-2R compared with only 1 +/- 1% lung CD8+ T cells (p less than 0.01). However, stimulation of purified sarcoid blood CD8+ T cells with the anti-T3/TCR complex mAb OKT3 was followed by the normal expression of IL-2R (p greater than 0.1) and proliferation (p greater than 0.1). In addition, lung sarcoid CD8+ T cells responded to OKT3 similarly to normal lung CD8+ T cells and to autologous blood CD8+ T cells as regards expression of IL-2R (p greater than 0.1) and proliferation (p greater than 0.1). Finally, using CD4+ cells activated with allogenic Ag to induce, in coculture, fresh autologous CD8+ cells to suppress proliferation of fresh autologous CD4+ cells to the same Ag, sarcoid CD8+ T cells suppressed CD4+ cell proliferation in a normal fashion (p greater than 0.1). These results demonstrate that sarcoid CD8+ (suppressor/cytotoxic) T cells are competent to respond to a proliferation signal normally and can be induced to normally suppress CD4+ T cell proliferation to Ag, suggesting that the expansion of activated CD4+ T cells in pulmonary sarcoidosis is not due to a generalized abnormality of CD8+ T cells or of their suppressor T cell function.

publication date

  • March 15, 1988

has subject area

  • Adult
  • Cells, Cultured
  • Female
  • Humans
  • Immune Tolerance
  • Lung Diseases
  • Lymphocyte Activation
  • Male
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • Sarcoidosis
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Regulatory

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 2964485

Additional Document Info

start page

  • 1854

end page

  • 1860

volume

  • 140

number

  • 6