Molecular crowding on the cell surface Academic Article uri icon

Overview

MeSH Major

  • Cell Membrane
  • Membrane Fluidity
  • Membrane Proteins

abstract

  • Strong steric interactions among proteins on crowded living cell surfaces were revealed by measurements of the equilibrium spatial distributions of proteins in applied potential gradients. The fraction of accessible surface occupied by mobile surface proteins can be accurately represented by including steric exclusion in the statistical thermodynamic analysis of the data. The analyses revealed enhanced, concentration-dependent activity coefficients, implying unanticipated thermodynamic activity even at typical cell surface receptor concentrations.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2962287

Additional Document Info

start page

  • 61

end page

  • 4

volume

  • 239

number

  • 4835