T-cell differentiation antigen cluster 2 (CD2) is a receptor for accessory cells and can generate and/or transduce accessory signals Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Breast Neoplasms
  • Hemangioblasts
  • Hematopoietic Stem Cells
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factor Receptor-2

abstract

  • The role of CD2 antigen in T-cell activation was investigated using soluble-phase or cross-linked monoclonal anti-CD2 antibodies. Soluble-phase anti-CD2 inhibited T-cell activation when accessory signals were provided with accessory cells and not when 12-0-tetradecanoyl-phorbol-13-acetate provided the accessory signals to anti-CD3-treated T cells. Soluble-phase anti-CD2 also inhibited anti-CD3 and accessory cell-dependent increases in intracellular free calcium concentration. Crosslinked anti-CD2, on the other hand, mediated an increase in the concentration of intracellular free calcium in T cells. Crosslinked anti-CD2 also functioned as an accessory cell substitute in that it generated the required accessory signals and mediated significant proliferation of anti-CD3-treated T cells. Collectively, these findings support the concept that the CD2 antigen is a receptor for accessory cells and participates in accessory signal generation and/or transduction.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0008-8749(88)90280-8

PubMed ID

  • 3257905

Additional Document Info

start page

  • 112

end page

  • 22

volume

  • 112

number

  • 1