Modified BFM therapy for children with previously untreated acute lymphoblastic leukemia and unfavorable prognostic features. Report of Children's Cancer Study Group Study CCG-193P. Academic Article uri icon

Overview

MeSH

  • Adolescent
  • Adult
  • Bone Marrow
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Humans
  • Infant
  • Leukocyte Count
  • Patient Compliance
  • Prognosis

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

abstract

  • The Children's Cancer Study Group's (CCG) clinical trials in acute lymphoblastic leukemia (ALL) prior to 1981 consistently demonstrated that patients presenting with a white blood cell count (WBC) greater than or equal to 50,000/microliter or the "lymphoma syndrome" had a less than 40% 3-year event-free survival (EFS). The Berlin Frankfurt Munster (BFM) 76/79 study suggested that the prognosis of these patients could be improved. Before testing this therapy in a randomized setting, 29 CCG institutions used it for treatment of 209 newly diagnosed children with ALL and an initial WBC greater than or equal to 50,000/microliter or the lymphoma syndrome. In the intensive phases of therapy, 77% of cumulative parenteral doses and 55% of cumulative oral doses were within 10% of protocol requirements or were modified appropriately for reported toxicity. One hundred ninety-five patients achieved remission (93.3%). Eleven patients died in remission (5.6%)--10 during the intensive reinduction/reconsolidation phase. The 4-year EFS (+/- 1 SD) was 62% (+/- 3.7%) with a median follow-up of 40 months. Only one patient has had an isolated CNS relapse. These results appear superior to past CCG studies for high-risk patients and extend observations made from studies of similar therapy.

publication date

  • 1988

has subject area

  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols
  • Bone Marrow
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Humans
  • Infant
  • Leukocyte Count
  • Patient Compliance
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Prognosis

Research

keywords

  • Clinical Trial
  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 3056061

Additional Document Info

start page

  • 42

end page

  • 50

volume

  • 10

number

  • 1