Presence of the Dr receptor in normal human tissues and its possible role in the pathogenesis of ascending urinary tract infection Academic Article uri icon

Overview

MeSH Major

  • Antigens, Bacterial
  • Blood Group Antigens
  • Escherichia coli Infections
  • Urinary Tract Infections

abstract

  • The Dr hemagglutinin of uropathogenic Escherichia coli recognizes the Dra blood group antigen, a component of the IFC or Cromer-related blood group complex. The present report used the Dr hemagglutinin to demonstrate location of the Dr receptor in selected human tissues and to evaluate the possible use of this lectin as a tissue marker recognizing sites sensitive for bacterial colonization. It was found that the Dr receptor was expressed in different parts of the digestive, urinary, genital, and respiratory tracts, and skin. Intense staining by Dr hemagglutinin was shown in colonic, bronchial, and endometrial glands, and skin eccrine sweat glands. Structures of the urinary tract showing strong fluorescence were renal tubular basement membrane, Bowmans' capsule, and transitional epithelium. The role of Dra antigen as receptor for adhesion for Dr-positive E. coli in ascending colonization of urinary tract and the possible importance of Dra in human pathology is discussed.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1880658

PubMed ID

  • 3052090

Additional Document Info

start page

  • 1

end page

  • 4

volume

  • 133

number

  • 1