Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor Academic Article uri icon

Overview

MeSH Major

  • Insulin
  • Lipoprotein Lipase
  • Phosphatidylinositols

abstract

  • Lipoprotein lipase (LPL) plays a critical role in the metabolism of plasma lipoproteins. In 3T3-L1 adipocytes, insulin elicits the rapid release of LPL through mechanisms that are independent of energy metabolism and protein synthesis. Some of the metabolic actions of insulin may be mediated by the activation of a specific phospholipase that hydrolyzes a glycosyl phosphatidylinositol (PI) molecule. The insulin-sensitive glycosyl-PI is structurally similar to the glycolipid membrane anchor of a number of proteins. LPL appears to be anchored to the 3T3-L1 cell surface by glycosyl-PI, and its rapid release by insulin may be due to activation of a glycosyl-PI-specific phospholipase C.

publication date

  • December 1988

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2843987

Additional Document Info

start page

  • 1670

end page

  • 2

volume

  • 241

number

  • 4873