Granulomatous pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome Academic Article uri icon


MeSH Major

  • Acquired Immunodeficiency Syndrome
  • Pneumonia, Pneumocystis


  • Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms' cysts. We recently studied two rare cases of P carinii pneumonia presenting as pulmonary nodules on chest x-ray films in two patients with AIDS. The corresponding histologies were a combination of the usual intra-alveolar pattern, with an alveolar and interstitial granulomatous appearance. Pneumocystis carinii was present in both areas and was the only organism found in the tissues examined. A third case presented with the more common radiographic appearance but also had a granulomatous histology. We conclude that P carinii pneumonia should be considered in the differential diagnosis of pulmonary nodules in immunocompromised patients and that pathologists should be aware of the possibility of a granulomatous reaction to this organism.

publication date

  • January 1988



  • Academic Article



  • eng

PubMed ID

  • 3261680

Additional Document Info

start page

  • 580

end page

  • 3


  • 94


  • 3