Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma Academic Article uri icon

Overview

MeSH Major

  • Burkitt Lymphoma
  • Exons
  • Mutation
  • Proto-Oncogenes
  • Transcription, Genetic
  • Translocation, Genetic

abstract

  • The c-myc proto-oncogene is involved in chromosomal translocations that are specifically and consistently found in Burkitt lymphoma. Although these translocations are thought to lead to a deregulation of c-myc expression, the structural and functional basis of this phenomenon has not been identified. Mutations in a specific region spanning approximately 70 base pairs and located at the 3' border of the first exon of translocated c-myc alleles were consistently detected in Burkitt lymphoma cells carrying classic (8:14) as well as variant (8:22 and 2:8) translocations. These structural alterations were accompanied by an altered pattern of c-myc transcription, namely, the removal of a block to transcriptional elongation that has been mapped to the same region. Thus, specific c-myc mutations leading to the alleviation of this block to transcriptional elongation may represent a general mechanism causing c-myc activation in Burkitt lymphoma.

publication date

  • December 1987

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3685977

Additional Document Info

start page

  • 1272

end page

  • 5

volume

  • 238

number

  • 4831