Generalized lymphadenopathy with morphologic features of Castleman's disease in an HIV‐positive man Academic Article Article uri icon


MeSH Major

  • Breast Neoplasms
  • Estrogen Receptor alpha
  • Gene Expression Regulation, Neoplastic
  • Inflammation
  • Obesity


  • In recent years the literature has described a highly lethal "multicentric" variant of classic Castleman's disease (CD) with similar hyperplastic angio-follicular morphologic features. A 44-year-old man who was not known to be part of any established high-risk group for the acquired immune deficiency syndrome (AIDS) presented with clinical and laboratory features similar to "multicentric" CD. Serologic testing revealed antibody to the human immunodeficiency virus (HIV) by Western blot analysis. It is suggested that "multicentric" CD may be part of the clinicopathologic spectrum of HIV infection, and there should be a high index of suspicion for HIV in patients presenting with generalized lymphadenopathy and histopathologic features of CD.

publication date

  • January 1987



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19871115)60:10<2454::AID-CNCR2820601018>3.0.CO;2-I

PubMed ID

  • 3478119

Additional Document Info

start page

  • 2454

end page

  • 8


  • 60


  • 10