Comparison of potential cytoprotective action of sucralfate and cimetidine. Studies with experimental feline esophagitis Academic Article uri icon


MeSH Major

  • Cimetidine
  • Esophagitis
  • Sucralfate


  • The potential mucosal protective effects of a liquid sucralfate preparation and the histamine (H2)-antagonist cimetidine on acid-induced esophagitis were studied. Esophagitis was induced in adult cats using a constant infusion of 0.1 N hydrochloric acid at 1 ml/minute for 20 minutes. Mucosal lesions were evaluated by blinded investigators using both fiber-optic endoscopy and light microscopy. Histology was scored for basal cell hyperplasia, intraepithelial leukocytosis, and subepithelial leukocytosis. Liquid sucralfate given prior to acid infusion consistently prevented acid-induced lesions, demonstrated by quantitative histologic scoring. Although cimetidine did not show the same degree of protection as sucralfate, the results did show a trend towards a cytoprotective effect.

publication date

  • September 28, 1987



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(87)90829-1

PubMed ID

  • 3661611

Additional Document Info

start page

  • 56

end page

  • 60


  • 83


  • 3 SUPPL. 2