Growth regulation of human breast carcinoma occurs through regulated growth factor secretion Review uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Estrogens
  • Growth Substances

abstract

  • We describe studies on human breast cancer in which it is shown that specific growth factors (IGF-I, TGF alpha, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone-dependent breast cancer and secreted constitutively by hormone-independent cells. These growth factor activities can induce the growth of hormone-dependent cells in vivo in athymic nude mice. Hormone-dependent breast cancer cells also secrete TGF beta, a growth-inhibitory substance, when treated with antiestrogens. TGF beta functions as a negative autocrine growth regulator and is responsible for some of the growth-inhibitory effects of antiestrogens.

publication date

  • January 1987

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/jcb.240350102

PubMed ID

  • 3312244

Additional Document Info

start page

  • 1

end page

  • 16

volume

  • 35

number

  • 1