Expression of MHC class I genes in mouse hepatitis virus (MHV-A59) infection and in multiple sclerosis. Academic Article uri icon


MeSH Major

  • Hepatitis, Viral, Animal
  • Major Histocompatibility Complex
  • Multiple Sclerosis


  • Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest that MHC class I restricted, cytotoxic T lymphocyte (CTL) reactions, against self or foreign antigens may play a role in these conditions. These findings may help to elucidate the mechanism of coronavirus-induced demyelination as well as the pathogenesis of multiple sclerosis.

publication date

  • December 1987



  • Academic Article



  • eng

PubMed ID

  • 2829530

Additional Document Info

start page

  • 219

end page

  • 22


  • 218