Endosome acidification and the pathways of receptor-mediated endocytosis. Review uri icon

Overview

MeSH Major

  • Endocytosis
  • Receptors, Cell Surface

abstract

  • Acidification of endocytic compartments occurs within 2-3 minutes following internalization. In CHO cells, three kinetically and morphologically distinct endocytic or recycling compartments can be identified. Measurements of the pH in these compartments show that the acidity of the compartments is regulated independently, although some parts of the acidification mechanism may be shared. The pH values found in these compartments provide a satisfactory explanation for various required steps in the endocytosis and recycling pathways. Further work is required to understand the biochemical basis for the pH regulation in various intracellular organelles.

publication date

  • December 1987

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 2839960

Additional Document Info

start page

  • 189

end page

  • 98

volume

  • 225