Noxythiolin in long term biliary and ureteric drainage
External biliary and drainage was established in six dogs, with the formation of incomplete distal obstruction in four. Drainage catheters were flushed twice daily with either saline or noxythiolin (2.5% w/v) in saline for alternate periods of four weeks. Saline flushing of drainage catheters was associated with the presence of large numbers of bacteria in bile and urine (> 109 organisms/ml) and resulted in significant weight loss, persistent leucocytosis and fever requiring antibiotic administration. By contrast, the use of noxythiolin was associated with elimination of bacteria from bile and urine, correlated with steady weight gain and protected against sepsis. Noxythiolin appears highly effective and free from adverse effects when used for the prevention of septic complications associated with long term external drainage.