Immunoglobulin and T cell receptor beta chain gene DNA probes in the diagnosis and classification of human lymphoid neoplasia Article Report uri icon

Overview

MeSH Major

  • Acquired Immunodeficiency Syndrome
  • Lymphoma, Non-Hodgkin

abstract

  • The application of DNA probes to demonstrate clonal rearrangements of the immunoglobulin heavy and light chain and T cell receptor beta chain gene loci by Southern blot hybridization analysis has led to significant advances in our ability to diagnose, classify and investigate the lymphoproliferative disorders. This approach has allowed us to conclusively determine the B or T cell lineage derivation and the clonal nature of the vast majority of lymphoid neoplasms, resulting in a new level of understanding of the biology of lymphoid neoplasia. Further application of these DNA probes to other poorly defined and controversial lymphoproliferative disorders should clarify their nature as well. Eventually, antigen receptor gene rearrangement analysis may become routinely employed in diagnosing lymphoid malignancies, monitoring the effects of chemotherapy, detecting early subclinical relapses and identifying disease progression, especially with respect to detecting the emergence of new clonal populations.

publication date

  • January 1987

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1016/0890-8508(87)90004-1

PubMed ID

  • 2840574

Additional Document Info

start page

  • 15

end page

  • 31

volume

  • 1

number

  • 1