Optimization of donor specific blood transfusion in kidney transplantation. Academic Article uri icon

Overview

MeSH Major

  • Blood Transfusion
  • Kidney Transplantation

abstract

  • 1. One hundred milliliters of stored whole blood DST, three times at weekly intervals is a practical, less immunizing and effective approach to enhance graft survival in recipients of a living-related donor kidney. 2. This protocol could also be used in sibling donor/recipient pairs who do not share a haplotype as well as in those who share two haplotypes to enhance graft survival. 3. The use of a short course of Cs (6 mg/kg/d for three weeks) along with DST appears to reduce the sensitization rate even lower. The dose of Cs used in this study produced no clinically significant adverse reactions, whereas Aza (1 mg/kg/d) often produces leukopenia. 4. DST produces significantly suppressed donor specific MLC responses in the early post-DST period; however, it increases the response at a later time. DST modulates immune responses in such a way that secondary responses upon grafting are more readily reversible by immunosuppressive agents.

publication date

  • February 1987

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2978891

Additional Document Info

start page

  • 2250

end page

  • 1

volume

  • 19

number

  • 1 Pt 3