Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. Academic Article uri icon

Overview

MeSH

  • Biological Assay
  • Cells, Cultured
  • Chemotaxis
  • Female
  • Fibroblasts
  • Humans
  • Male
  • Middle Aged
  • Proto-Oncogenes

MeSH Major

  • Macrophages
  • Platelet-Derived Growth Factor
  • Pulmonary Alveoli
  • Pulmonary Fibrosis

abstract

  • Idiopathic pulmonary fibrosis is a fibrotic lung disease characterized by an increased number of mesenchymal cells in the alveolar walls. Alveolar macrophages constitutively express low levels of c-sis, the protooncogene coding for the B chain of platelet-derived growth factor, a protein with chemotactic and mitogenic activity toward mesenchymal cells. We therefore hypothesized that alveolar macrophages in patients with idiopathic pulmonary fibrosis may release increased amounts of platelet-derived growth factor, which might help to explain the accumulation of mesenchymal cells and the fibrosis of the lower respiratory tract in the disease. Evaluation of alveolar macrophages recovered from the lungs of patients with idiopathic pulmonary fibrosis demonstrated that these cells spontaneously released four times more platelet-derived growth factor than did alveolar macrophages recovered from normal persons (P less than 0.01). That the platelet-derived growth factor molecules were potentially active was shown by their chemotactic activity for smooth-muscle cells and their ability to act as a "competence" factor for fibroblast growth. These observations suggest the possibility that the accumulation of mesenchymal cells within the alveolar walls in patients with idiopathic pulmonary fibrosis may result partly from the exaggerated release of the potent mitogen platelet-derived growth factor by mononuclear phagocytes in the lower respiratory tract.

publication date

  • July 23, 1987

has subject area

  • Biological Assay
  • Cells, Cultured
  • Chemotaxis
  • Female
  • Fibroblasts
  • Humans
  • Macrophages
  • Male
  • Middle Aged
  • Platelet-Derived Growth Factor
  • Proto-Oncogenes
  • Pulmonary Alveoli
  • Pulmonary Fibrosis

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM198707233170404

PubMed ID

  • 3600711

Additional Document Info

start page

  • 202

end page

  • 209

volume

  • 317

number

  • 4