Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes Academic Article Article uri icon


MeSH Major

  • Holistic Health
  • Holistic Nursing
  • Nurse's Role
  • Philosophy, Nursing
  • Practice Patterns, Nurses'


  • Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

publication date

  • March 1987



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/BF00712736

PubMed ID

  • 3111077

Additional Document Info

start page

  • 129

end page

  • 35


  • 411


  • 2