Abnormal temporal lobe response in Alzheimer's disease during cognitive processing as measured by 11C-2-deoxy-D-glucose and PET Academic Article uri icon


MeSH Major

  • Alzheimer Disease
  • Temporal Lobe
  • Tomography, Emission-Computed


  • Elderly controls and probable Alzheimer's disease patients underwent serial positron emission tomography (PET) studies during a baseline condition and while performing a verbal memory task. For the temporal lobes, all 7 Alzheimer patients demonstrated a relative shift in glucose metabolic rates to the right hemisphere during the memory condition relative to baseline, and 5 of 7 controls showed a shift to the left hemisphere. Baseline absolute regional metabolic rates replicate previous findings and were somewhat less useful than the memory challenge in differentiating patients from controls. These results indicate that a temporal lobe abnormality in Alzheimer's disease is related to memory performance.

publication date

  • January 1987



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1038/jcbfm.1987.50

PubMed ID

  • 3494029

Additional Document Info

start page

  • 248

end page

  • 51


  • 7


  • 2