Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract. Academic Article Article uri icon

Overview

MeSH

  • 6-Ketoprostaglandin F1 alpha
  • Adult
  • Arachidonic Acid
  • Body Fluids
  • Dinoprost
  • Epithelium
  • Female
  • Humans
  • Lung
  • Male
  • Prostaglandins E
  • Prostaglandins F
  • Thromboxane B2

MeSH Major

  • Arachidonic Acids
  • Prostaglandin-Endoperoxide Synthases
  • Respiratory System

abstract

  • Cyclooxygenase metabolites of arachidonic acid are thought to play an important role in the regulation of diverse physiological functions in the lung. Although the concentration of these metabolites required to have effects is several orders of magnitude greater than the concentration of these mediators in the blood, it has been postulated that local concentrations within tissues are much higher. In a direct test of this hypothesis, the concentrations of the cyclooxygenase products of arachidonic acid including prostaglandin (PG) E, PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, were measured in a specialized tissue compartment, the epithelial surface of the lower respiratory tract. The concentration of these mediators within this compartment was 50- to 80-fold greater than concurrent blood levels and are sufficient to likely have physiological effects. Thus the epithelial surface of the lower respiratory tract represents a specialized compartment with high local levels of cyclooxygenase products of arachidonic acid.

publication date

  • January 1987

has subject area

  • 6-Ketoprostaglandin F1 alpha
  • Adult
  • Arachidonic Acid
  • Arachidonic Acids
  • Body Fluids
  • Dinoprost
  • Epithelium
  • Female
  • Humans
  • Lung
  • Male
  • Prostaglandin-Endoperoxide Synthases
  • Prostaglandins E
  • Prostaglandins F
  • Respiratory System
  • Thromboxane B2

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 3104286

Additional Document Info

start page

  • 219

end page

  • 222

volume

  • 62

number

  • 1