Histidine-rich glycoprotein inhibits the antiproliferative effect of heparin on smooth muscle cells. Academic Article uri icon

Overview

MeSH

  • Animals
  • Aorta
  • Cattle
  • Cell Division
  • Cells, Cultured
  • Heparin Antagonists

MeSH Major

  • Heparin
  • Muscle, Smooth, Vascular
  • Proteins

abstract

  • Histidine-rich glycoprotein (HRGP), an alpha-glycoprotein in human plasma that is also present in platelets and macrophages, binds heparin with high affinity and neutralizes its anticoagulant activity. We now report that HRGP specifically inhibits the antiproliferative effect of heparin on arterial smooth muscle cells while other heparinoid-binding proteins do not influence mitogenesis. The multicellular inflammatory response to endothelial injury characterized, in part, by the influx of platelets and macrophages, may be associated with HRGP release into the arterial microenvironment. This release of HRGP may allow smooth muscle cell proliferation and atherogenesis by inhibiting the action of endothelial cell-derived heparinoid substances.

publication date

  • March 1, 1987

has subject area

  • Animals
  • Aorta
  • Cattle
  • Cell Division
  • Cells, Cultured
  • Heparin
  • Heparin Antagonists
  • Muscle, Smooth, Vascular
  • Proteins

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2188292

PubMed ID

  • 3819648

Additional Document Info

start page

  • 908

end page

  • 913

volume

  • 165

number

  • 3