Selective inhibition of nociceptive flexion reflex discharge by the kappa agonist bremazocine Academic Article Article uri icon

Overview

MeSH Major

  • Geriatric Assessment
  • Psychiatric Status Rating Scales

abstract

  • In unanaesthetized decerebrate spinal cats, bremazocine (0.012-0.2 mg/kg, i.v.) selectively inhibited the late C-fibre reflex discharge, recorded in sectioned lumbo-sacral ventral root filaments, after supramaximal electrical stimulation of the ipsilateral sural or common peroneal nerve. This action was naloxone-reversible. The results suggest that activation of kappa opioid receptors in the spinal cord inhibits the integration of nociceptive, but not locomotor, flexion reflexes.

publication date

  • January 1987

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0028-3908(87)90219-X

PubMed ID

  • 3035416

Additional Document Info

start page

  • 271

end page

  • 4

volume

  • 26

number

  • 2-3