Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein Academic Article uri icon

Overview

MeSH Major

  • Demyelinating Diseases
  • Glycoproteins
  • Immunoglobulin M
  • Myelin Proteins
  • Paraproteinemias

abstract

  • Demyelination of feline sciatic nerve was induced by intraneural injection of serum from three patients with neuropathy and an IgM M-protein that reacted with myelin-associated glycoprotein (MAG). Demyelination exceeded that induced by serum from 18 other individuals, including six IgM M-proteins unreactive with MAG. The myelinolytic effect required active human complement and was abolished by exposure of serum to homogenate of human peripheral nerve that removed 90% of the M-protein. Immunofluorescence studies demonstrated deposition of the injected M-protein and complement on the surface of myelin sheaths, implying that the M-protein reacted with epitopes of myelin exposed to the extracellular space.

publication date

  • January 1987

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2433641

Additional Document Info

start page

  • 242

end page

  • 56

volume

  • 37

number

  • 2